{"id":242020,"date":"2022-09-30T12:28:23","date_gmt":"2022-09-30T10:28:23","guid":{"rendered":"https:\/\/polishscience.pl\/?p=242020"},"modified":"2022-09-30T12:28:23","modified_gmt":"2022-09-30T10:28:23","slug":"a-new-way-to-design-drugs-developed-at-the-warsaw-university-of-technology","status":"publish","type":"post","link":"https:\/\/www.polishscience.pl\/en\/a-new-way-to-design-drugs-developed-at-the-warsaw-university-of-technology\/","title":{"rendered":"A new way to design drugs developed at the Warsaw University of Technology"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">A team from the Faculty of Chemistry at the Warsaw University of Technology (PW) has developed a new drug design procedure that can be used when few experimental data are available on the molecular mechanisms of a disease and its treatment modalities. The results of the work have been published in the Journal of Biomolecular Structure and Dynamics.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the university, the developed procedure is the result of the work of a student, Stanis\u0142aw Kulczyk, and Dr Eng. Mariola Koszytkowska-Stawi\u0144ska, professor of engineering at PW.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&#8216;We used a method that involves designing a drug based on the structure of the protein interacting with it, which reduced the amount of experimental data needed,&#8217; says Prof. Koszytkowska-Stawi\u0144ska.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The first method was combined with a second method using smaller, known structural fragments (fragment-based approach). This accelerated the design process.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The second stage of the procedure involved giving the pre-designed molecules the most favourable properties from the point of view of their potential medical application, explains Stanis\u0142aw Kulczyk. This stage was carried out using a proprietary computer algorithm.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read more:<\/span><\/p>\n<p><a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/07391102.2022.2110519?journalCode=tbsd20\"><span style=\"font-weight: 400;\">https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/07391102.2022.2110519?journalCode=tbsd20<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team from the Faculty of Chemistry at the Warsaw University of Technology (PW) has developed a new drug design procedure that can be used when few experimental data are available on the molecular mechanisms of a disease and its treatment modalities. The results of the work have been published in the Journal of Biomolecular [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":241904,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[27],"tags":[],"_links":{"self":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/posts\/242020"}],"collection":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/comments?post=242020"}],"version-history":[{"count":0,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/posts\/242020\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/media\/241904"}],"wp:attachment":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/media?parent=242020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/categories?post=242020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/tags?post=242020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}