{"id":190415,"date":"2021-08-12T15:10:19","date_gmt":"2021-08-12T13:10:19","guid":{"rendered":"https:\/\/polishscience.pl\/?p=190415"},"modified":"2021-08-12T15:10:19","modified_gmt":"2021-08-12T13:10:19","slug":"biologist-from-the-university-of-lodz-joins-a-pakistani-scientific-team-searching-a-more-effective-treatment-for-atherosclerosis","status":"publish","type":"post","link":"https:\/\/www.polishscience.pl\/en\/biologist-from-the-university-of-lodz-joins-a-pakistani-scientific-team-searching-a-more-effective-treatment-for-atherosclerosis\/","title":{"rendered":"Biologist from the University of Lodz joins a Pakistani scientific team searching a more effective treatment for atherosclerosis"},"content":{"rendered":"<p><strong>Dr\u00a0Micha\u0142 Ponczek from the Faculty of Biology and Environmental Protection of the University of Lodz (U\u0141), together with scientists from Pakistan, developed a method for detecting inhibitors of the PCSK9 protein, which may enable the development of more effective drugs for atherosclerosis.\u00a0The mechanism was described in the PLOS ONE magazine.<\/strong><\/p>\n<p>Subtilisin \/ Kexin-9 Proprotein Convertase (PCSK9) is one of the proteins contributing to elevated cholesterol levels and the onset of atherosclerosis.<\/p>\n<p>The work\u00a0&#8220;Finding inhibitors for PCSK9 using computational methods&#8221;\u00a0describes a method of finding potential PCSK-9\u00a0inhibitors using computational methods\u00a0(thanks to advanced computer technologies).\u00a0Such chemical compounds could become new anti-atherosclerotic drugs in the future.<\/p>\n<p>Dr\u00a0Micha\u0142 Ponczek explained, that PCSK-9 inhibitors could partially replace the long-known statins or be used together with them to prevent blood vessel blockage, leading to fatal strokes and heart attacks.<\/p>\n<p>More:<br \/>\n<a href=\"https:\/\/translate.google.com\/translate?hl=ru&amp;prev=_t&amp;sl=pl&amp;tl=en&amp;u=https:\/\/journals.plos.org\/plosone\/article\/metrics%3Fid%3D10.1371\/journal.pone.0255523\">https:\/\/journals.plos.org\/plosone\/article\/metrics?id=10.1371\/journal.pone.0255523<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr\u00a0Micha\u0142 Ponczek from the Faculty of Biology and Environmental Protection of the University of Lodz (U\u0141), together with scientists from Pakistan, developed a method for detecting inhibitors of the PCSK9 protein, which may enable the development of more effective drugs for atherosclerosis.\u00a0The mechanism was described in the PLOS ONE magazine. Subtilisin \/ Kexin-9 Proprotein Convertase [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[27],"tags":[],"_links":{"self":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/posts\/190415"}],"collection":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/comments?post=190415"}],"version-history":[{"count":0,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/posts\/190415\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/media?parent=190415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/categories?post=190415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.polishscience.pl\/en\/wp-json\/wp\/v2\/tags?post=190415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}